Independent Spirit Award for Best Female Lead

The Film Independent's Spirit Award for Best Female Lead is one of the annual Independent Spirit Awards.

Winners and nominees

1980s

• 1985: Geraldine Page - The Trip to Bountiful
  • Rosanna Arquette - After Hours
  • Laura Dern - Smooth Talk
  • Lori Singer - Trouble in Mind
• 1986: Isabella Rossellini - Blue Velvet
  • Elpidia Carrillo - Salvador
  • Patricia Charbonneau - Desert Hearts
  • Laura Dern - Blue Velvet
  • Tracy Camilla Johns - She's Gotta Have It

2000s

• 2002: Julianne Moore - Far From Heaven
  • Jennifer Aniston - The Good Girl
  • Catherine Keener - Lovely & Amazing
  • Parker Posey - Personal Velocity: Three Portraits
  • Maggie Gyllenhaal - Secretary
• 2003: Charlize Theron - Monster
  • Agnes Bruckner - Blue Car
  • Zooey Deschanel - All the Real Girls
  • Samantha Morton - In America
  • Elisabeth Moss - Virgin
• 2004: Catalina Sandino Moreno - Maria Full of Grace
  • Kimberly Elise - Woman Thou Art Loosed
  • Vera Farmiga - Down to the Bone
  • Judy Marte - On the Outs
  • Kyra Sedgwick - Cavedweller
• 2005: Felicity Huffman - Transamerica
  • Dina Korzun - Forty Shades of Blue
  • Laura Linney - The Squid and the Whale
  • S. Epatha Merkerson - Lackawanna Blues
  • Cyndi Williams - Room
• 2006: Shareeka Epps - Half Nelson
  • Catherine O'Hara - For Your Consideration
  • Robin Wright Penn - Sorry, Haters
  • Elizabeth Reaser - Sweet Land
  • Michelle Williams - Land of Plenty
• 2007: Ellen Page - Juno
  • Angelina Jolie - A Mighty Heart
  • Sienna Miller - Interview
  • Parker Posey - Broken English
  • Tang Wei - Lust, Caution (Sè, jiè)
• 2008: Melissa Leo - Frozen River
  • Summer Bishil - Towelhead
  • Anne Hathaway - Rachel Getting Married
  • Tarra Riggs - Ballast
  • Michelle Williams - Wendy and Lucy

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