International Classification of Diseases for Oncology

The International Classification of Diseases for Oncology (ICD-O) is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries.

It is currently in its third revision (ICD-O-3). ICD-10 includes a list of morphology codes. They stem from ICD-O second edition (ICD-O-2) that was valid at the time of publication.

1 Axes
- 1.1 Morphology
  - 1.1.1 Examples of codes (ICD-O-3)
- 1.2 Topography
2 See also
3 External links
- 3.1 Morphology

Axes

The classification has two axes:

Morphology

The morphology axis is for the morphology of the tumor.

This axis has additional importance, because the Systematized Nomenclature of Medicine(SNOMED) has adopted ICD-O's classification of morphology. SNOMED has been changing continuously, and several different versions of SNOMED are in use. Accordingly, mapping of ICD-O codes to SNOMED requires careful assessment whether entities really match, or not.

Examples of codes (ICD-O-3)

(8850-8880) Lipomatous neoplasms
- (M 8850/0) Lipoma, NOS
- (M 8850/3) Liposarcoma, NOS

(8890-8920) Myomatous neoplasms
- (M 8890/0) Leiomyoma, NOS
- (M 8890/3) Leiomyosarcoma, NOS
- (M 8895/0) Myoma
- (M 8895/3) Myosarcoma
- (M 8900/0) Rhabdomyoma, NOS
- (M 8900/3) Rhabdomyosarcoma, NOS

(8930-8990) Complex Mixed And Stromal Neoplasms
- (M 8940/0) Pleomorphic adenoma
- (M 8960/3) Nephroblastoma, NOS (Wilms's tumor)

(9000-9030) Fibroepithelial Neoplasms
- (M 9000/0) Brenner tumor, NOS

(9040-9049) Synovial-Like Neoplasms
- (M 9040/3) Synovial sarcoma, NOS

(9050-9059) Mesothelial Neoplasms
- (M 9050/0) Mesothelioma, benign
- (M 9050/3) Mesothelioma, NOS

(9060-9090) Germ cell Neoplasms
- (M 9060/3) Dysgerminoma
- (M 9064/3) Germ cell tumor, NOS
- (M 9070/3) Embryonal carcinoma, NOS
- (M 9071/3) Yolk sac tumor
- (M 9080/0) Teratoma, benign
- (M 9080/3) Teratoma, malignant, NOS
- (M 9084/0) Dermoid cyst, NOS

(9100-9109) Trophoblastic neoplasms
- (M 9100/3) Choriocarcinoma, NOS

(9110-9119) Mesonephromas
(9120-9160) Blood vessel tumors
- (M 9120/0) Hemangioma, NOS
- (M 9120/0) Angioma, NOS
- (M 9120/3) Hemangiosarcoma
- (M 9120/3) Angiosarcoma
- (M 9130/0) Hemangioendothelioma, benign
- (M 9130/1) Hemangioendothelioma, NOS
- (M 9140/3) Kaposi's sarcoma
- (M 9150/0) Hemangiopericytoma, benign
- (M 9150/1) Hemangiopericytoma, NOS

(9170-9179) Lymphatic vessel tumors
- (M 9170/0) Lymphangioma, NOS
- (M 9173/0) Cystic lymphangioma

(9180-9240) Osseous And Chondromatous neoplasms
- (M 9180/0) Osteoma, NOS
- (M 9180/3) Osteosarcoma, NOS
- (M 9210/0) Osteochondroma
- (M 9210/0) Cartilaginous exostosis
- (M 9220/0) Chondroma, NOS
- (M 9220/3) Chondrosarcoma, NOS

(9250-9259) Giant cell tumors
(9260-9269) Miscellaneous bone tumors
- (M 9260/3) Ewing's sarcoma

(9270-9340) Odontogenic tumors
- (M 9273/0) Cementoblastoma, benign
- (M 9310/0) Ameloblastoma, NOS

(9350-9370) Miscellaneous tumors
- (M 9350/1) Craniopharyngioma

(9380-9589) Nervous system

(9380-9480) Gliomas
- (M 9382/3) Mixed oligoastrocytoma
- (M 9391/3) Ependymoma, NOS
- (M9400/3) Astrocytoma, NOS
  - (9421/3) Pilocytic astrocytoma
  - (9440/3) Glioblastoma multiforme
- (M 9450/3) Oligodendroglioma, NOS

(9490-9520) Neuroepitheliomatous neoplasms
- (M 9500/3) Neuroblastoma, NOS
- (M 9510/3) Retinoblastoma

(9530-9539) Meningiomas

(9540-9570) Nerve sheath tumors
- (M 9540/0) Neurofibroma, NOS
- (M 9540/1) Neurofibromatosis, NOS
- (M 9560/0) Schwannoma, NOS
- (M 9560/0) Neurinoma
- (M 9560/0) Acoustic neuroma
- (M 9570/0) Neuroma, NOS

(9580-9589) Granular cell tumors and Alveolar soft part sarcoma

(9590-9999) Hematologic (Leukemias, Lymphomas and related disorders)

(9590-9599) Malignant lymphoma, NOS, Or diffuse
- (M 9590/3) Lymphoma, NOS
- (M 9591/3) Non-Hodgkin's lymphoma, NOS
- (M 9592/3) Lymphosarcoma, NOS

(9650-9660) Hodgkin's disease

(9670-9680) Malignant lymphoma Specified Type, Diffuse Or Nos
- (M 9670/3) Small lymphocytic lymphoma
- (M 9671/3) Lymphoplasmacytic lymphoma
- (M 9673/3) Mantle cell lymphoma
- (M 9678/3) Primary effusion lymphoma
- (M 9679/3) Mediastinal (thymic) large cell lymphoma
- (M 9680/3) Diffuse large B-cell lymphoma or Intravascular large B-cell lymphoma
- (M 9687/3) Burkitt lymphoma
- (M 9689/3) Splenic marginal zone lymphoma

(9690-9699) Malignant lymphoma, Follicular Or Nodular, With Or Without diffuse areas

(9700-9709) Specified Cutaneous And Peripheral T-Cell Lymphomas
- (M 9700/3) Mycosis fungoides
- (M 9701/3) Sezary syndrome
- (M 9702/3) Peripheral T-cell lymphoma, unspecified
- (M 9705/3) Angioimmunoblastic T-cell lymphoma
- (M 9708/3) Subcutaneous panniculitis-like T-cell lymphoma

(9710-9719) Other Specified Non-Hodgkin's lymphomas

(9720-9729) Other Lymphoreticular neoplasms
- (M 9727/3) Blastic NK cell lymphoma
- (M 9728/3) Lymphoma
- (M 9729/3) Lymphoma

(9730-9739) Plasma cell tumors
- (M 9731/3) Plasmacytoma, NOS or Extramedullary plasmacytoma or Solitary plasmacytoma of bone
- (M 9732/3) Multiple myeloma or Plasma cell myeloma
- (M 9734/3) Extraosseous plasmacytoma

(9740-9749) Mast cell Tumors
- (M 9740/1) Mastocytoma, NOS or Extracutaneous mastocytoma
- (M 9740/3) Mast cell sarcoma
- (M 9741/1) Malignant mastocytosis or Indolent systemic mastocytosis
- (M 9741/3) Aggressive systemic mastocytosis or Systemic mastocytosis with associated clonal, hematological non-mast cell lineage disease
- (M 9742/3) Mast cell leukemia
- (M 9751/1) Langerhans cell histiocytosis
- (M 9755/3) Histiocytic sarcoma
- (M 9756/3) Langerhans cell sarcoma
- (M 9757/3) Dendritic cell sarcoma, NOS or Interdigitating dendritic cell sarcoma/tumor
- (M 9758/3) Follicular dendritic cell sarcoma/tumor

(9760-9769) Immunoproliferative diseases
- (M 9761/3) Waldenstrom macroglobulinemia
- (M 9766/1) Lymphomatoid granulomatosis

-- Lymphoid leukemias, and related conditions

(9800-9809) Leukemias, NOS
- (M 9800/3) Leukemia, NOS
- (M 9805/3) Acute leukemia of ambiguous lineage
- (M 9801/3) Acute leukemia, NOS

(9820-9829) Lymphoid leukemias
- (M 9820/3) Lymphocytic leukemia, NOS
- (M 9820/3) Lymphatic leukemia, NOS
- (M 9821/3) Acute lymphoblastic leukemia, NOS
- (M 9821/3) Acute lymphocytic leukemia
- (M 9823/3) Chronic lymphocytic leukemia
- (M 9826/3) Leukemia
- (M 9827/3) Adult T-cell leukemia/lymphoma

(9830-9839) Plasma cell leukemia
- (M 9831/3) T-cell large granular lymphocytic leukemia
- (M 9833/3) B-cell prolymphocytic leukemia
- (M 9834/3) T-cell prolymphocytic leukemia
- (M 9835/3) Precursor cell lymphoblastic leukemia, NOS
- (M 9836/3) Precursor B lymphoblastic leukemia
- (M 9837/3) Precursor T lymphoblastic leukemia

-- Myeloid leukemias, and related conditions

(9840-9849) Erythroleukemias (FAB-M6)
- (M 9840/3) Acute erythroid leukemia

(9850-9859) Lymphosarcoma cell leukemia

(9860-9869) Myeloid (Granulocytic) Leukemias
- (M 9860/3) Myeloid leukemia, NOS
- (M 9860/3) Myelogenous leukemia, NOS
- (M 9861/3) Acute myelogenous leukemia (FAB-M1,M2)
- (M 9863/3) Chronic myelogenous leukemia
- (M 9866/3) Acute promyelocytic leukemia (FAB-M3)
- (M 9866/3) Acute promyelocytic leukemia (AML with t(15;17)(q22;q12), PML-RARa and variants)
- (M 9867/3) Acute myelomonocytic leukemia (FAB-M4)

(9870-9889) Basophilic leukemia and Eosinophilic leukemia
- (M 9870/3) Basophilic leukemia or Acute basophilic leukemia
- (M 9871/3) AML with inv(16)(p13q22) or t(16;16)(p13;q22), CBFb/MYH11 (FAB M4Eo)
- (M 9872/3) Acute myeloid leukemia, minimally differentiated (FAB type M0)
- (M 9873/3) Acute myeloid leukemia, without maturation (FAB type M1)
- (M 9874/3) Acute myeloid leukemia, with maturation (FAB M2)
- (M 9875/3) Chronic myelogenous leukemia
- (M 9876/3) Atypical chronic myelogenous leukemia
- (M 9880/3) Eosinophilic leukemia

(9890-9899) Monocytic leukemias
- (M 9890/3) Monocytic leukemia, NOS (FAB-M5)
- (M 9891/3) Acute monoblastic and monocytic leukemia (FAB M5)
- (M 9895/3) Acute myeloid leukemia multilineage dysplasia
- (M 9896/3) AML with t(8;21)(q22;q22), AML1/ETO
- (M 9897/3) AML with 11q23 (MLL) abnormalities

(9900-9948) Other Leukemias
- (M 9910/3) Acute megakaryoblastic leukemia (FAB-M7)
- (M 9920/3) Acute myeloid leukemia and myelodysplastic syndrome, therapy related
- (M 9930/3) Chloroma or Myeloid sarcoma
- (M 9931/3) Acute panmyelosis with myelofibrosis
- (M 9940/3) Hairy cell leukemia
- (M 9946/3) Juvenile myelomonocytic leukemia
- (M 9948/3) Aggressive NK cell leukemia

-- Other

(9950-9970) Miscellaneous Myeloproliferative And Lymphoproliferative disorders
- (M 9950/3) Polycythemia vera
- (M 9960/1) Myeloproliferative disease, NOS
- (M 9961/3) Chronic idiopathic myelofibrosis
- (M 9962/3) Essential thrombocytemia
- (M 9963/3) Chronic neutrophilic leukemia
- (M 9964/3) Chronic eosinophilic leukemia / hypereosinophilic syndrome
- (M 9970/1) Post-transplant lymphoproliferative disorder, pleomorphic
- (M 9975/3) Chronic Myeloproliferative disease, unclassifiable
- (M 9975/3) Myelodysplastic / myeloproliferative diseases, unclassifiable

(9980-9989) Myelodysplastic syndrome

Topography

The topography axis is for the topographical codes of the tumor's site. It is standardized with the C section of ICD-10

There were no changes in the topography axis between ICD-O-2 and ICD-O-3.

See List of ICD-10 codes#.28C00-C97.29 Malignant Neoplasms for examples.

External links

Official page at World Health Organization
Tutorial at National Cancer Institute
Overview at DIMDI
Overview of multiple primaries at healthyarkansas.com (PPT)
History of versions at National Cancer Institute

Morphology

Cancer.gov - overview, includes link to Excel spreadsheet with codes at National Cancer Institute
Overview at National Cancer Institute
Word document - malignancies only at National Cancer Institute
Overview at University hospital Gießen und Marburg
Download table German version at DIMDI
Codes at IARC
1st, 2nd, and 3rd editions at wolfbane.com
List at The National Cancer Registry Ireland
List at London School of Hygiene & Tropical Medicine

Glandular and epithelial neoplasms (ICD-O 8010-8589)

Epithelium

Papilloma/carcinoma
(8010-8139)

Small cell carcinoma · Verrucous carcinoma · Squamous cell carcinoma · Basal cell carcinoma · Transitional cell carcinoma · Inverted papilloma

Glands

Adenomas/
adenocarcinomas
(8140-8429)

Adnexal and
skin appendage (8390-8429)

sweat gland (Hidrocystoma, Syringoma) · Syringocystadenoma papilliferum

Cystic, mucinous,
and serous (8440-8499)

Cystic general	Cystadenoma/Cystadenocarcinoma

Mucinous	Signet ring cell carcinoma (Krukenberg tumor) · Mucinous cystadenoma/Mucinous cystadenocarcinoma (Pseudomyxoma peritonei) · Mucoepidermoid carcinoma

Serous	Serous cystadenoma/Serous cystadenocarcinoma/Papillary serous cystadenocarcinoma

Ductal, lobular,
and medullary (8500-8549)

Ductal carcinoma	Mammary ductal carcinoma · Pancreatic ductal carcinoma · Comedocarcinoma · Paget's disease of the breast/Extramammary Paget's disease

Lobular carcinoma	Lobular carcinoma in situ · Invasive lobular carcinoma

Medullary carcinoma	Medullary carcinoma of the breast · Medullary thyroid cancer

Acinar cell (8550-8559)

Acinic cell carcinoma

Other


Complex epithelial (8560-8589)	Warthin's tumor · Thymoma

Gonadal tumors, paraganglioma, glomus, nevi and melanomas (ICD-O 8590-8799)

Gonadal/
sex cord-gonadal stromal (8590-8679)

sex cord (Granulosa cell tumour, Sertoli cell tumor)

stroma (Thecoma, Leydig cell tumor)

both (Sertoli-Leydig cell tumour, Luteoma)

Paragangliomas And
Glomus tumors (8680-8719)

Neuroendocrine tumor: Paraganglioma (Pheochromocytoma)

Vascular tissue neoplasm: Glomus tumor (Glomangiosarcoma)

Nevi and melanomas (8720-8799)

Nevi	Melanocytic/pigmented nevus (Mongolian spot, Blue nevus, Nevus of Ota, Spitz nevus) location (Junctional nevus, Compound nevus) Halo nevus · Dysplastic nevus

Melanomas (NE)	Superficial spreading melanoma · Nodular melanoma · lentigo (Lentigo maligna/Lentigo maligna melanoma, Acral lentiginous melanoma)

Connective/soft tissue tumors and sarcomas (ICD-O 8800-9059) (C45-C49/D17-D21, 171/214-215)

Not otherwise specified (8800-8809)

Soft tissue sarcoma · Desmoplastic small round cell tumor

Connective tissue neoplasm

Fibromatous (8810-8839)	Fibroma/fibrosarcoma: Dermatofibrosarcoma · Dermatofibrosarcoma protuberans · Desmoplastic fibroma Histiocytoma/histiocytic sarcoma: Benign fibrous histiocytoma · Malignant fibrous histiocytoma

Myxomatous (8840-8849)	Myxoma/myxosarcoma · Angiomyxoma · Ossifying fibromyxoid tumour

Fibroepithelial (9000-9039)	Brenner tumour · Fibroadenoma · Phyllodes tumor

Synovial-like (9040-9049)	Synovial sarcoma · Clear-cell sarcoma

Lipomatous (8850-8889)

Lipoma/liposarcoma (Myelolipoma, Myxoid liposarcoma) · PEComa (Angiomyolipoma)

Myomatous (8890-8929)

general: Myoma/myosarcoma

smooth muscle: Leiomyoma/leiomyosarcoma

skeletal muscle: Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma (Sarcoma botryoides) · Alveolar rhabdomyosarcoma

Complex Mixed And Stromal (8930-8999)

Adenomyoma · Pleomorphic adenoma · Mixed Müllerian tumor · Mesoblastic nephroma · Wilms' tumor · Rhabdoid tumour · Clear-cell sarcoma of the kidney · Hepatoblastoma · Pancreatoblastoma · Carcinosarcoma

Mesothelial (9050-9059)

Mesothelioma · Adenomatoid tumor

muscle, DF+DRCT navs: anat/hist/physio, acquired myopathy/congenital myopathy/neoplasia, symptoms+signs/eponymous, proc, meds:M (1A/3)

v • d • e Germ cell tumors (ICD-O 9060-9119) (C45-C49/D17-D21, 171/214-215)

Germinomatous	Germinoma (Seminoma, Dysgerminoma)

Nongerminomatous	Embryonal carcinoma Mesonephroma: Endodermal sinus tumor/Yolk sac tumor Teratoma: Fetus in fetu · Dermoid cyst · Struma ovarii Trophoblastic neoplasm: Gestational trophoblastic disease (Hydatidiform mole) · Choriocarcinoma Polyembryoma Gonadoblastoma

v • d • e Vascular tissue neoplasm (ICD-O 9120-9179) (C49/D18, 171/215)

Blood	Hemangioma/hemangiosarcoma · Blue rubber bleb nevus syndrome · Hemangioendothelioma (Infantile hemangioendothelioma) · Kaposi's sarcoma · Hemangiopericytoma · Angiokeratoma · Capillary hemangioma (Hemangioblastoma) · Cavernous hemangioma

Lymphatic	Lymphangioma/lymphangiosarcoma · PEComa (Lymphangioleiomyomatosis) · Cystic hygroma

Either	Angioma/angiosarcoma · Angiofibroma

vascular navs: anat/physio/dev, noncongen/systemic vasculitis/congen/neoplasia, symptoms+signs/eponymous, proc lymphatic organ navs: anat, physio, lymphatic disease/splenic disease/thymus disorders/thymus neoplasia/vascular tumors, proc

Connective tissue neoplasm: Osseous and Chondromatous tumors (ICD-O 9180-9269) (C40-C41/D16, 170/213)

Diaphysis


Myeloid	Multiple myeloma

Epithelial	Adamantinoma

PNET/Ewing family	Ewing's sarcoma

Metaphysis

Osteoblast	Osteoid osteoma · Osteoblastoma Osteoma/osteosarcoma

Chondroblast	Chondroma/ecchondroma/enchondroma (Enchondromatosis) · Chondrosarcoma (Mesenchymal chondrosarcoma, Myxoid chondrosarcoma) Osteochondroma (Osteochondromatosis) Chondromyxoid fibroma

Fibrous	Ossifying fibroma · Fibrosarcoma

Epiphysis

Chondroblast	Chondroblastoma

Myeloid	Giant cell tumor of bone

Other/ungrouped

Notochord

Chordoma

bone/cartilage: anat/physio/dev, noncongen/congen/neoplasia, symptoms+signs/eponymous signs, proc, drugs:M (5)

v • d • e Odontogenic tumors (ICD-O 9270-9349)

Cementoblast	Cementoblastoma · Cementoma

Ameloblast	Ameloblastoma

Mixed/hamartoma	Odontoma

Other	Adenomatoid odontogenic tumor

tooth navs: anat/dev, disease/neoplasia, proc

Nervous tissue tumors/nervous system neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72/D32-D33, 191-192/225)

Endocrine/
sellar (9350-9379)

sellar: Craniopharyngioma · Pituicytoma

other: Pinealoma

CNS (9380-9539)

Neuroepithelial
(brain tumors,
spinal tumors)

Meningiomas (meninges)

Meningioma

Hematopoietic

Primary central nervous system lymphoma

PNS: NST (9540-9579)

cranial and paraspinal nerves: Neurofibroma (Neurofibrosarcoma, Neurofibromatosis) · Neurilemmoma/Schwannoma (Acoustic neuroma) · Malignant peripheral nerve sheath tumor

note: not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see brain metastases)
CNS: anat/physio/dev, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc, medsN (1A/2AB/2C/3/4/5A/5B/5C/6A/6B/6D/7A/7B/7C/7D)
peripheral nervous system navs: anat/histo/physio/dev, noncongen PNS somatic/autonomic/congen/neoplasia, symptoms+signs/eponymous, proc

Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590-9739, 9800-9839)

B cell
(lymphoma,
leukemia)
(most CD19, CD20)

By development/
marker

TdT+	ALL (Precursor B acute lymphoblastic leukemia/lymphoma)

CD5+	naive B cell (CLL/SLL) mantle zone (Mantle cell)

CD22+	Prolymphocytic · CD11c (Hairy cell leukemia)

CD79a+	germinal center/follicular B cell (Follicular, Burkitt's, GCB-DLBCL) marginal zone/marginal-zone B cell (Splenic marginal zone, MALT, Nodal marginal zone)

RS (CD15+,CD30+)	Classic Hodgkin's lymphoma (Nodular sclerosis) · CD20 (Nodular lymphocyte predominant Hodgkin's lymphoma)

PCDs/PP (CD38+/CD138+)	see immunoproliferative immunoglobulin disorders

By infection

KSHV (Primary effusion) · EBV (Lymphomatoid granulomatosis, Post-transplant lymphoproliferative disorder) · HIV (AIDS-related lymphoma) · Helicobacter pylori (MALT lymphoma)

T/NK

T cell
(lymphoma,
leukemia)
(most CD3, CD4, CD8)

By development/ marker	TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma) prolymphocyte (Prolymphocytic) CD30+ (Anaplastic large cell, Lymphomatoid papulosis)

By location/peripheral	Cutaneous (Mycosis fungoides, Sézary's disease) · Hepatosplenic · Angioimmunoblastic · Enteropathy-associated T-cell lymphoma

By infection	HTLV-1 (Adult T-cell leukemia/lymphoma)

NK cell/
(most CD56)

Aggressive NK-cell leukemia · Blastic NK cell lymphoma

T or NK

EBV (Extranodal NK-T-cell lymphoma) · Large granular lymphocytic leukemia

Lymphoid+myeloid

Acute biphenotypic leukaemia

Lymphocytosis

Lymphoproliferative disorders (X-linked lymphoproliferative disease, Autoimmune lymphoproliferative syndrome) · Leukemoid reaction · Pseudolymphoma

lymphocyte navs: cells/physio, immunodeficiency/immunoproliferative immunoglobulin/neoplasia, proc

Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)

CFU-GM/
and other granulocytes

MEP

CFU-Meg	AML (AMKL/M7) MP (Essential thrombocytosis)

CFU-E	AML (Erythroleukemia/M6) MP (Polycythemia vera) MD (Refractory anemia, Refractory anemia with excess of blasts, Chromosome 5q deletion syndrome, Sideroblastic anemia, Paroxysmal nocturnal hemoglobinuria, Refractory cytopenia with multilineage dysplasia)